Effect of morin on glycoproteins and membrane bound enzymes in streptozotocin-induced diabetic rats

This study investigated the effect of morin on membrane bound enzymes and glycoproteins in normal and streptozotocin (STZ)-induced diabetic Wistar rats. Diabetes was induced in rats by an intraperitoneal injection of STZ, dissolved in citrate buffer (0.01 M, pH 4.5) and injected to overnight fasted rats with a dose of STZ 50 mg/kg. Morin was dissolved in carboxy methyl cellulose (CMC) at a dose of 100 mg/kg and given to rats orally for a period of 45 d. In diabetic rats, the levels of glycoproteins were significantly increased in plasma and tissues (liver and kidney) and activities of membrane bound enzymes significantly decreased in liver and kidney. In addition, morin treatment significantly prevents the histopathological alterations in STZ-induced rats. Thus, morin exhibits beneficial role on membrane bound enzymes and glycoproteins in STZ-induced diabetic rats.